Molecular characterization of TGF-β mediated cancer cell proliferation

TGF-β inhibits epithelial cell growth through Smad-dependent induction of a cell cycle arrest at G1. During tumor progression, however, many tumor cells escape from TGF-β growth suppression due to either functional or genetic disruption of the Smad signaling pathway. In late tumor stages, TGF-β s...

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Bibliographic Details
Main Author: Singh, Garima
Contributors: Ellenrieder, Volker (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2010
Online Access:PDF Full Text
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