Molecular characterization of TGF-β mediated cancer cell proliferation

TGF-β inhibits epithelial cell growth through Smad-dependent induction of a cell cycle arrest at G1. During tumor progression, however, many tumor cells escape from TGF-β growth suppression due to either functional or genetic disruption of the Smad signaling pathway. In late tumor stages, TGF-β s...

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Bibliographic Details

Main Author:	Singh, Garima
Contributors:	Ellenrieder, Volker (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2010
Subjects:	Transforming Growth Factor beta Medizin Medical sciences Medicine
Online Access:	PDF Full Text
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