Molecular characterization of TGF-β mediated cancer cell proliferation

TGF-β inhibits epithelial cell growth through Smad-dependent induction of a cell cycle arrest at G1. During tumor progression, however, many tumor cells escape from TGF-β growth suppression due to either functional or genetic disruption of the Smad signaling pathway. In late tumor stages, TGF-β s...

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Bibliographic Details
Main Author: Singh, Garima
Contributors: Ellenrieder, Volker (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2010
Innere Medizin
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Call Number: urn:nbn:de:hebis:04-z2010-02671
Downloads: 206 (2021), 201 (2020), 181 (2019), 124 (2018), 108 (2017)
Publication Date: 2010-05-27
License: According to UrhG § 31 (2), the author has granted the University Library Marburg the right of use for electronic publication on the Internet and for archiving on its archive server. He has declared that with the granting of the right of use according to UrhG § 31 (3) no exclusive rights of third parties are violated. All other rights for the exploitation of the publication remain with the author.
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