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Kopplung der Cyclooxygenase 2 an sekundäre Enzyme
Die NSAR gehören zu den weltweit am häufigsten eingenommenen Schmerzmedikamenten. Sie hemmen die Cylooxygenase 1 und 2, Enzyme, die für die Produktion von Schmerzmediatoren (Prostaglandine) verantwortlich sind. Durch die unselektive Hemmung beider Cylooxygenasen kommt es jedoch auch zu der Hemmu...
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| Format: | Doctoral Thesis |
| Language: | German |
| Published: |
Philipps-Universität Marburg
2010
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| Online Access: | PDF Full Text |
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My thesis is about the preference of cyclooxygenase 2 over prostacyclin synthase. I mutated the C terminus of cyclooxygenase 2 and then analysed the production of prostaglandins. My research revealed that the C terminus removal results in a lower production of prostacyclin. It can thus be concluded that the C terminus plays a significant role in the preference of cyclooxygenase 2 over prostacylin synthase.