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Toxicological Evaluation of Poly(ethylene imine) -based non-viral vector systems for pulmonary siRNA application

In this thesis, toxicity of PEI-based non-viral vector systems for siRNA application into the lungs was comprehensively described and analyzed in vitro as well as in vivo. Chapter 1 introduced in basic information about the lung anatomy and physiology and general considerations for pulmonary appli...

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Bibliographic Details
Main Author: Beyerle, Andrea
Contributors: Kissel, Thomas (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2010
Subjects:
RNS-Interferenz
Toxikologische Bewertung
Naturwissenschaften
inflammation
Wasserlösliche Polymere
Oxidativer Stress
Poly(ethylene imine)
oxidative stress
pulmonary application
Entzündung
In vivo
Lunge
Cytotoxizität
In vitro
siRNA
Polyethylenimin (PEI)
Cytotoxicity
Natural sciences & mathematics
Online Access:PDF Full Text
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