Purpurmembran: Ein affines 2D-Templat

Das Archaeon Halobacterium salinarum besiedelt extrem halophile Lebensräume. Bei anaeroben Bedingungen wird das integrale Membranprotein Bakteriorhodopsin exprimiert. Bakteriorhodopsin (BR) ist eine lichtgesteuerte Protonenpumpe und spielt eine Schlüsselrolle in der Energiegewinnung der Zelle. BR is...

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Bibliographic Details
Main Author: Heidel, Björn
Contributors: Hampp, Norbert (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2009
Online Access:PDF Full Text
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Extreme halophilic environments are the habitat of the archaeon Halobacterium salinarum. Anaerobic pressure leads to the expression of the integral membrane protein bacteriorhodopsin (BR). As a light-driven proton pump it exemplifies a vectorial catalysis which is optimized for ATP-synthesis. BR is ordered to two‑dimensional crystalline hexagonal structure: the Purple Membrane (PM). For biotechnical applications on surfaces and the construction of hybrid structures a specific monolayered orientation must be achieved. Therefore specific genetic modifications of BR are necessary.