The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The presented study contributes to the fundamental understanding of molecular recognition of small molecules by a macromolecular host protein. The biophysical properties of a large set of systematically varied thrombin inhibitors were anatomized in detail. In particular the combination of structural...

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Bibliographic Details
Main Author: Baum, Bernhard
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2009
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Call Number: urn:nbn:de:hebis:04-z2009-06981
Publication Date: 2009-11-24
Date of Acceptance: 2009-08-28
Downloads: 88 (2024), 148 (2023), 204 (2022), 240 (2021), 330 (2020), 289 (2019), 131 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2009/0698
https://doi.org/10.17192/z2009.0698