Systematische Analyse von Rezeptoren und Effektormechanismen der pulmonalen angeborenen Immunität

Das Atemwegsepithel bildet eine Grenzfläche zwischen dem Körperinneren und unserer Umwelt. Es ist einerseits eine physikalische Barriere und verhindert das Eindringen von pathogenen Mikroorganismen und Fremdkörpern. Andererseits ist es aber auch aktiv an der angeborenen Immunität beteiligt. In diese...

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Bibliographic Details
Main Author: Stanze, Daniel
Contributors: Gemsa, D. (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2009
Online Access:PDF Full Text
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The airway epithelium is an important interface with the environment, and represents a dynamic system for innate host defense. In addition to providing a barrier to the entry of pathogens, epithelial cells lining the airway have been shown to respond to the presence of microorganisms by producing natural antimicrobial factors and mounting an inflammatory response. Toll-like receptors (TLR) play an important role in pathogen recognition and innate immunity. To date ten family members of the TLR family are known in the human genome. In this study the expression and function of the TLR 1-10 in different epithelial cell-lines of the lung and primary cells were explored and compared with each other. In addition we explored the expression and function of TLR 1-10 in endothelial primary cells. In this study the expression of the antimicrobial peptide psoriasin (S100A7) in the lung could be shown.