Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens...

Full description

Bibliographic Details

Main Author:	Hoffmann-Geim, Frank
Contributors:	Buckel, Wolfgang (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2009
Subjects:	Modellierung Biowissenschaften, Biologie Carbonyl-Reductase Hydroxysteroid-Dehydrogenasen Röntgenstruktur SDR Simulation Molecular dynamic Hydroxysteroiddehydrogenase Molekulardynamik Drug Design 3alpha HSD/CR Life sciences
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!