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Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens...

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Bibliographic Details
Main Author: Hoffmann-Geim, Frank
Contributors: Buckel, Wolfgang (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2009
Subjects:
Modellierung
Biowissenschaften, Biologie
Carbonyl-Reductase
Hydroxysteroid-Dehydrogenasen
Röntgenstruktur
SDR
Simulation
Molecular dynamic
Hydroxysteroiddehydrogenase
Molekulardynamik
Drug Design
3alpha HSD/CR
Life sciences
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Call Number: urn:nbn:de:hebis:04-z2009-05639
Publication Date: 2009-10-08
Date of Acceptance: 2009-07-17
Downloads: 167 (2024), 91 (2023), 45 (2022), 41 (2021), 35 (2020), 66 (2019), 33 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2009/0563
https://doi.org/10.17192/z2009.0563

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