Vergleich der Ergebnisse der Knochendichte gemessen mittels Dualer Röntgenabsorptiometrie (DXA) und Quantitativer Ultrasonometrie bei Patientinnen mit primärem Mammakarzinom und gesunden gleichaltrigen Frauen

Zusammenfassung Hintergrund Das Mammakarzinom und die Osteoporose sind zwei bedeutende Erkrankungen, die aufgrund ihrer Häufigkeit eine immer größere Rolle spielen. In mehreren Studien wurde ein inverser Zusammenhang zwischen diesen Krankheiten gezeigt. Dabei wird der Östrogenstoffwechsel als e...

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Bibliographic Details
Main Author: Jäger, Claudia
Contributors: Hadji, Peyman (Prof. Dr.med.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2009
Subjects:
DXA
QUS
Online Access:PDF Full Text
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Table of Contents: Breast cancer and osteoporosis are two important diseases. Both are influenced by estrogens. For breast cancer estrogens seem to be a risk factor, in contrast to osteoporosis. Here estrogens seem to be protective. In this study we analyse if it´s possible to show this inverse correlation between these two diseases by measuring bone mineral density with DXA and QUS. Therefore we chose pre- and postmenopausal women with primary breast cancer and healthy controls. We measured bone mineral density at lumbar spine and total hip and ultrasound parameters at the os calcaneus with QUS. After matched pair analysis and odds ratio calculation we came to the results, that patients with primary breast cancer do have higher BMD measured with DXA and QUS. Women with higher BMD measured by DXA and QUS seem to have a higher risk for breast cancer.