TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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Bibliographic Details
Main Author: Ritschel, Tina
Contributors: Klebe, Gerhard (Prof., Dr.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2009
Pharmazeutische Chemie
Online Access:PDF Full Text
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