TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

Full description

Saved in:
Bibliographic Details
Main Author: Ritschel, Tina
Contributors: Klebe, Gerhard (Prof., Dr.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2009
Pharmazeutische Chemie
Subjects:
TGT
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!