TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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Bibliographic Details
Main Author: Ritschel, Tina
Contributors: Klebe, Gerhard (Prof., Dr.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2009
Pharmazeutische Chemie
Subjects:
TGT
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Call Number: urn:nbn:de:hebis:04-z2009-04739
Downloads: 58 (2021), 101 (2020), 97 (2019), 56 (2018), 64 (2017)
Publication Date: 2009-10-09
License: According to UrhG § 31 (2), the author has granted the University Library Marburg the right of use for electronic publication on the Internet and for archiving on its archive server. He has declared that with the granting of the right of use according to UrhG § 31 (3) no exclusive rights of third parties are violated. All other rights for the exploitation of the publication remain with the author. https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2009/0473
https://doi.org/10.17192/z2009.0473