TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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Bibliographic Details

Main Author:	Ritschel, Tina
Contributors:	Klebe, Gerhard (Prof., Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2009
Subjects:	pKa shifts Englisch TGT Computational chemistry Enzymkinetik tRANA X-ray Kristallographie X-ray crystallography Enzyminhibitor tRNA pKa-Shifts Arzneimitteldesign Enzyme kinetic English
Online Access:	PDF Full Text
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