Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...

Full description

Bibliographic Details

Main Author:	Böttcher, Jark
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2008
Subjects:	Pyrrolidines HIV protease HIV-Proteaseinhibitor Chemie Molekulardesign Protein crystallography Strukturbasiertes Wirkstoffdesign Structure-based inhibitor design Proteinkristallographie Arzneimitteldesign Pyrrolidinderivate Chemistry & allied sciences
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!