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Untersuchungen zur ligandenvermittelten Regulation der Melanocortin-Rezeptor-Aktivität

Die vorliegende Arbeit stellt die Ergebniss von Untersuchungen zur ligandenvermittelten Regulation der Melanocortin-Rezeptor-Aktivität dar. Melanocortin-Rezeptoren (MCR) spielen eine entscheidende Rolle in der Regulation des Energiehaushalts. Für den Melanocortin-4-rezeptor (MC4R) ist bekannt, dass...

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Bibliographic Details
Main Author: Wolff, Katharina
Contributors: Gudermann, Thomas (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2009
Subjects:
Endocytose
Melanotropin
D90N
Arrestin
Medizin
AgRP
MCR
GPCR
Agouti
Medical sciences Medicine
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Melanocortin-Receptors are playing an important role in the maintenance of energy homeostasis. Alpha-MSH a Melanocortin-Receptor agonist induces arrestin-mediated Endocytosis of the Melanocortin-3-Receptor (MC3R). Similar effects have already been shown for the Melanocortin-4-Receptor (MC4R). Agouti-related-Protein the natural inverse agonist of MCR also induces arrestin-mediated endocytosis of MC3R and MC4R. The MC4R mutant D90N which has lost the ability of G-Protein-Activation recruits beta-arrestin after agonist-stimulation but does not show endocytosis.

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