Proliferation und Apoptose in Abhängigkeit der N-Myc-Amplifikation im humanen Neuroblastom und ihre prognostische Bedeutung

Das Neuroblastom ist der häufigste solide extrakranielle Tumor im Kindesalter. Als entscheidendes molekulares Prognosekriterium hat sich die Amplifikation des N-Myc-Genes etabliert. Kinder mit amplifiziertem N-Myc-Gen haben eine signifikant geringere Überlebenswahrscheinlichkeit als solche ohne. U...

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Bibliographic Details
Main Author: Dahms, Julian
Contributors: Christiansen, Holger (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2008
Online Access:PDF Full Text
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Neuroblastoma is the most common solid extracranial tumour in childhood. Its most important molecular prognostic marker is the amplification of MYCN. Patients with amplified MYCN gene show a significantly poorer prognosis than others. However, the reason why MYCN amplification is associated with a more aggressive phenotype is still uncertain. MYCN is shown to increase cellular proliferation as well as apoptosis. By investigating proliferation and apoptosis of primary neuroblastomas and correlating the results with MYCN amplification and clinical outcome it is hypothesized that the influence on prognosis of MYCN amplification can not be explained by its effect on proliferation neither on apoptosis.