Siderophore in Ustilago maydis: Synthese, Transport, Funktion und Regulation

Der phytopathogene Basidiomycet Ustilago maydis besitz zwei hoch-affine Eisenaufnahmesysteme. Das Permease-basierte System ist wichtig für die Virulenz. U. maydis ist in der Lage die beiden Siderophore Ferrichrom und Ferrichrom A zu synthetisiseren. Es konnten 6 neue Enzyme identifiziert werden, die...

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Bibliographic Details
Main Author: Winterberg, Britta
Contributors: Kahmann, Regine (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2008
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Table of Contents: The phytopathogenic basidiomycete U. maydis acquires iron via two high-affinity iron upatke systems. The permease-based system is essentiell for virulence of U. maydis. In addition U. maydis produces the two siderophores ferrichrome and ferrichrome A. I identified 6 new enzymes that are involved in siderophore biosynthesis. Furthermore, it was posssible to identify siderophore im- and exporters. While the siderophores are dispensable for vireulence, they are crucial for iron storage in the vacuoles, the cytoplasm and the spores. The two high-affinity iron uptake systems are differentially regulated during biotrophic development within the host plant maize. This regulation is achived in response to H2O2 produced by the palnt as defense signal.