Intermediärfilament- und GD2-Expression in astrozytären Hirntumoren
In der Arbeit wird eine vergleichende, semiquantitative immunhistochemische Untersuchung der Expression von saurem Gliafaserprotein, Vimentin und Glykosphingolipid GD2 in 28 astrozytären Hirntumoren WHO Grad II-IV dargestellt. Statistisch findet sich eine hohe Korrelation sowohl der intrazellulären...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2008
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| Online Access: | PDF Full Text |
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By means of immunhistochemical markers the expression of glial fibrillary acidic protein, vimentin and glykosphingolipid GD2 is investigated in 28 astrocytic tumors grading WHO II-IV. Statistically, there is found a high correlation in the cytoplasmatic expression of GFAP/GD2 as well as Vimentin/GD2 and GFAP/Vimentin.The semiquantitatively strongest expression was found in gemistocytic and protoplasmatic cells of the investigated glial tumors. As conclusion, astrocytic tumors express in a similar way intermediary filament GFAP and glykosphingolipid GD2. Whether or not a co-localisation of intermediary filaments and GD2 within the brain tumors takes place, remains open.