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Protonen- und Elektronenströme in humanen Monozyten

In dieser Arbeit sind Protonen- und Elektronenströme in humanen Monozyten simultan mit Hilfe der „Patch-Clamp“-Technik gemessen worden. Sie untersucht den durch die NADPHox generierten Elektronenstrom in anderen Zellen als Eosinophilen, Neutrophilen und Osteoklasten. Die Produktion von Sauerstoff...

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Bibliographic Details
Main Author: Musset, Boris
Contributors: Voigt, Karlheinz (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2008
Subjects:
Phagocyt
Phagozytose
Spannungssensor
H2O2
Proton
Phagozyt
Electron
Immunsystem
Elektrophysiologie
PKC
Radikal <Chemie>
Protonenstrom
Patch-Clamp-Methode
Medizin
Zink
Monozyt
Sauerstoffradikale
Monocyt
Medical sciences Medicine
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Proton and electron current was simultan measured in this publication using the patch clamp technique. Protoncurrent in human Monocytes do have the same biophysical characteristics than in other human phagocytes. But in contrary neutrophils and eosinophils it is possible to cultivate them for longer periods in vitro. Flourescence measurements confirmed the electrophysiological results. This work contributes to the understanding of the respiratory burst and its function plus the intracellular mechanism.

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