Wirksamkeit und Verträglichkeit von intraoperativ intravenös verabreichtem Paracetamol und Parecoxib sowie deren Kombination zur Optimierung der postoperativen Analgesie bei mammachirurgischen Eingriffen
Postoperative Schmerzen werden von Patienten in der Regel als einem operativen Eingriff immanent zugehörig betrachtet. Daher fordern nur wenige Patienten aktiv Schmerzmittel an. Dies führt letztlich jedoch durch verlängerte Immobilisation, verzögerte Genesung und eine höhere Wahrscheinlichkeit, post...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2008
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| Online Access: | PDF Full Text |
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Preemptive Analgesie is still a problem in perioperative medicine. We evaluated the effectiveness and safety of intraoperative intravenous given proparacetamol, parecoxib and a combination of both versus placebo. The aim was to reduce the need of supportive opioid and in consequence to reduce the incidence of typical opioidrelated sideeffects by using this not opioid based analgesia. We found no significant effects in patients undergoing elective mamma surgery.In total, pain levels very low (20-30mm evaluated with a vas-scale). 58% of the patients of the placebo group did not need any further opioid-medication versus 80-85% in the verum-groups but we did not achieve statistical significance. As these results show, patients of this collective had no benefit of preemtive analgesia therefore we can not recommend intravenous paracetamol, parecoxib or a combination of both as a standard treatment.