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Klonierung der Human Airway Trypsin-like Protease und Untersuchungen zu ihrer Fähigkeit der Aktivierung des Influenza A-Virus Hämagglutinins

Zur Aktivierung des Influenza A-Virus muss während des Replikationszyklus in der Zelle das Oberflächenprotein Hämagglutinin durch eine Wirtsprotease gespalten werden, um infektiöse Tochterviren generieren zu können. Die humanen Aktivierungsproteasen, die für diesen Prozess bei der Influenzavirusinfe...

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Bibliographic Details
Main Author: Beyerle, Michaela H.
Contributors: Garten, Wolfgang (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2008
Subjects:
HAT
Human Airway Trypsin-like Protease
Hämagglutinin
Influenza-A-Virus
Cleavage
Hemagglutinin
Serinproteinasen
Medizin
Grippe
Spaltung
Medical sciences Medicine
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For its activation, the Influenza A-Virus Hemagglutinin has to be cleaved by serine proteases of its host. By now the human serine proteases, which account for cleavage and activation of Influenza A-Virus Hemagglutinin during its replication cycle in the human host are still not identified. The cloning of the Human Airway Trypsin-like Protease and studies on its ability of cleaving Influenza A-Virus Hemagglutinin are main subjects of this work.

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