Mikrosatelliteninstabilität und Mismatch-Repairgenexpression in Adenomen bei erblichen Dickdarmkarzinom (HNPCC)

Erkrankungen des Magen – Darm – Traktes mit 2 – 5%, in einigen Studien sogar bis zu 30%, die größte Gruppe der ererbten Tumorerkrankungen. Es scheint sich dabei um eine polymorph vererbte Erkrankung zu handeln, deren Diagnose trotz zahlreicher Fortschritte immer noch schwierig ist. Die große Sch...

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Bibliographic Details
Main Author: Beckmann, Carmen
Contributors: Rüschoff, Josef (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2008
Online Access:PDF Full Text
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Among the malignant diseases of the gastro-intestinal (GI) tract, the hereditary non-polyposis colorectal cancer (HNPCC) builds the largest group of hereditary tumor diseases, with percentages ranging from with 2-5% up to 30%, depending on the study. The (HNPCC) seems to be a polymorphic inherited disease; despite progress, diagnosis is still difficult. The large variability of prevalences in epidemiological studies results from these diagnostic difficulties. Diagnosis is based on the anamnesis, initially developed 1913 by A. Warthin and later refined by the Amsterdam– and Bethesda-Criteria. The advantage of a carcinoma in the GI-tract is that it proceeds in several steps from normal tissue over adenoma up to the final stage of a carcinoma. Accordingly, an adenoma could help to predict a future carcinoma. Adenoma might bear the key to the problems described above, and they are relatively easy to examine using coloscopy, but at the moment they are not adequately examined. This study aims at examining temporal, immuno-histochemical and histological perspectives of adenoma and their microsatellite status in patients with a HNPCC diagnosis.