Analyse von Polymorphismen wichtiger Entzündungsmediatoren bei Patienten mit COPD und Bronchialkarzinomen

Die chronisch obstruktive Lungenerkrankung (COPD) und das Bronchialkarzinom (BC) sind weltweit häufige Erkrankungen von großer volkswirtschaftlicher Bedeutung, mit weiter stegender Inzidenz. Bei derzeit fehlenden kurativen Therapiemöglichkeiten für die COPD und der weiterhin schlechten Prognose der...

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Bibliographic Details
Main Author: Plagens, Alexandra
Contributors: Seifart, Carola (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2008
Online Access:PDF Full Text
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COPD and lung cancer are important diseases with high economic impact and increasing incidence worldwide. Caused by missing curative therapeutic options for COPD and at least bad prognosis for lung cancer patients it seems to be point of interest in looking for etiopathogenetic factors of this diseases. In this work polymorphisms of genes of the cytokines TNF-alpha and beta, interleukin 6 and 10 has been investigated in patients with COPD and lung cancer in a case control study. In patients with COPD an in a lung cancer subgroup there was a significant higher frequency of the IL-10 -1082_G polymorphism. The correlation of this polymorphism with the developement of COPD or lung cancer demonstrates a connection between immunological and antiinflamatory processes in the airways with the pathogenesis of these diseases. Also this SNP association could be a factor for risk stratification as well as for serological typing in clinical practice.