Neue Zielgene des Transkriptionsfaktors E2F-1 und die transkriptionelle Regulation des MYCN Onkogens im humanen Neuroblastom

Das Neuroblastom ist der häufigste solide pädiatrische Tumor außerhalb des ZNS. Eine Amplifikation und Expression des Onkogens MYCN im Neuroblastom geht, im Vergleich zu anderen Neuroblastomen, mit einer sehr ungünstigen Prognose einher. An der Regulierung der MYCN-Expression sind Die E2F-Transk...

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Bibliographic Details
Main Author: Kramps, Christoph Matthias
Contributors: Lutz, Werner (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2007
Online Access:PDF Full Text
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Table of Contents: The neuroblastoma is the most common solid pediatric tumor outside the central nervous system. The amplification and expression of the oncogene MYCN in neuroblastoma is associated with a very poor prognosis. The regulation of the MYCN expression is controlled by E2F transcription factors, which can in turn be activated by myc proteins. In addition to previously known E2F-1 activated genes it could be shown that the BMI-1 gene is also regulated by E2F-1. The Bmi1 protein is a member of the polycomb group of proteins that are known to have oncogenic functions. In a second project MYCN promotor-specific proteins could be enriched by means of affinity chromatography. This provides the basis for future characterisation of possible MYCN activating transcription factors.