Laser-getriggerte Freisetzung polymergebundener pharmazeutischer Wirkstoffe zur Behandlung des Nachstars

Krankheiten stellen seit Menschengedenken Probleme für die Menschheit dar, die zu heilen, die Ursachen zu verstehen und sie zu vermeiden von jeher das Anliegen der Medizin und der angrenzenden Wissenschaften war und ist. Das seit Jahrhunderten angesammelte vielfältige Wissen darüber, kombiniert mit...

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Bibliographic Details
Main Author: Härtner, Sebastian
Contributors: Hampp, Norbert (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2006
Online Access:PDF Full Text
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Table of Contents: Diseases represent problems for mankind within living memory, to heal, the causes to understand and it avoid always the request of the medicine and the adjacent sciences was and is. The various knowledge about, it accumulated for centuries, combined with the existing newest physical and chemical technologies, opens a comprehensive understanding for their causes and thus for their possibilities of treatment, as one could not introduce oneself it still years ago. One of main successes in the treatment of diseases was in the last decades the development and the employment of synthetically manufactured chemical-pharmaceutical medicaments, like for example Omeprazol or Risperidon. All these medicaments have in common, that they are given usually orally or by means of syringe, with the disadvantage, that a high percentage of the active active substance by metabolisation is more or less deactivated and separated afterwards. It is not available thereby for the therapy of the illness any longer. Particularly with the treatment with oncological medicines it is desirable, to possess possibilities of the purposeful administration. Therefore it is a goal of the pharmaceutical institutes researching today and the pharmaceutical industry, to synthesize or developed a active substance in form of the medicament in such a way, that the metabilisation is omitted as far as possible, so that the active substance at the place of the happening in high concentration is available and can unfold its desired effect. Newest research results within the range of the oncology are concerned with the purposeful giving of medicines into the goal cells, in order to expose the surrounding cell fabric to the effect medicine. These new administration methods are described by the term drug targeting. Two examples of newer methods drug targeting for the treatment of tumors are on the one hand merging cytostatic drugs in liposomes and on the other hand tying up cytostatic drugs to magnetic nano-particles. Apart from these newer methods also the possibility exists to bind the active substance to a not active polymer, to set free and these then at the destination by physical methods again. That has the advantage, that the active substance molecule is not attacked and as such in active form at the destination is only set free. A goal of the available work is the attempt, to bind pharmaceutical active substances to a polymer/copolymer and by laser Triggering or off the influence of photons again, without the active substance molecule is damaged. The chemical synthesis of photochemical active polymers is described in the work. Further of the active substance copolymers in such a way specified model intra ocular lenses are made and examined on the basis those to the postulated goal. of the work laser-triggered release of polymere-bound pharmaceutical active substances for the treatment of the next acre. Whereupon constructing the hit synthesis way to the production of the photochemically activatable copolymer was optimized and thus the possibility opens different active substances synthetically to tie. From the copolymers resulting from it the active substances are photochemically induced set free and their activity in vitro cell attempts is comparatively tested on.