Untersuchung möglicher Zusammenhänge zwischen koronarer Herzerkrankung und parodontaler Erkrankung. Auswertung verschiedener Subgruppen

Die koronare Herzkrankheit (KHK) gehört zu den häufigsten Todesursachen in den Industrienationen. In den letzten Jahren weisen Forschungsergebnisse verstärkt darauf hin, dass Infektionen eine entscheidende Bedeutung in der Pathogenese dieser Erkrankung haben könnten. Auch Parodontitis scheint ein Ri...

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Bibliographic Details
Main Author: Völkner, Ingrid
Contributors: Stelzel, Michael (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2007
Online Access:PDF Full Text
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Background: Many epidemiological and intervention studies have suggested that infections are risk factors for coronary heart disease (CHD). Periodontitis have appeared as cordiovascular risk facors in cross-sectional and follow-up studies. Methods: 232 patients who were hospitalized for coronary angiography between september 2000 and april 2001. Cases were patients with CHD proven by coronary angiography. Controls were patients without CHD, proven by coronary angiography. Both were given a clinical periodontal examination comprising assessment, periodontal pocket depth, clinical attachment level at four sites per tooth, bleeding on probing, gingival recession and plaque index. Information on blood pressure, serum cholesterol, body-mass-index, age, sex, diabetes and smoking was obtained. Results: CHD patients were statistically significantly older than controls (p=0,000) and most of them were men (p=0,000). Higher age is associated with higher clinical attachment level (p=0,000), gingival recession (p=0,000) and periodontal pocket depth (p=0,000). Clinical attachment level (p=0,000), bleeding on probing (p=0,016), gingival recession (p=0,000) and periodontal pocket depth were higher among CHD patients than in controls. Diabetes were significantly higher among cases (p=0,016) than in controls. Conclusion: The results are in accordance with those of several previous studies. They addicted to show only a discreet advice of this possible correlation. The number of samples is to low. If the results reflect a causal link between periodontal diseases and CHD they emphasize the need for better control of periodontal diseases. If the associations are-non-causal, they still demonstrate that CHD and periodontal diseases cluster in the same sections of the population.