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Novel imantib resistance mechanisms in chronic myloid leukemia

In my research, I found that the compensatory activation of PI3K/AKT/mTor signaling pathway contributes early imatinib resistance in LAMA cell models. We also found that the auto/paracrine of GM-CSF by imatinib resistant leukemic cells confers to potent imatinib and nilotinib resistance. These findi...

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Main Author: Wang, Ying
Contributors: Neubauer, Andreas (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2007
Subjects:
PI3K/Akt pathway
Conditioned medium
Medizin
Imatinib resistance
GM-CSF
Chronic myeloid leukaemia
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2007-03098
Publication Date: 2007-05-09
Date of Acceptance: 2007-04-26
Downloads: 16 (2025), 64 (2024), 32 (2023), 53 (2022), 71 (2021), 46 (2020), 49 (2019), 29 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2007/0309
https://doi.org/10.17192/z2007.0309

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