Novel imantib resistance mechanisms in chronic myloid leukemia

In my research, I found that the compensatory activation of PI3K/AKT/mTor signaling pathway contributes early imatinib resistance in LAMA cell models. We also found that the auto/paracrine of GM-CSF by imatinib resistant leukemic cells confers to potent imatinib and nilotinib resistance. These findi...

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Bibliographic Details
Main Author: Wang, Ying
Contributors: Neubauer, Andreas (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2007
Online Access:PDF Full Text
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