Evaluation verschiedener Applikationsparameter im Rahmen der lokalen intraarteriellen Pharmakotherapie zur Restenoseprophylaxe nach Ballonangioplastie - eine vergleichende tierexperimentelle Studie
Die in etwa 30-60% auftretende Restenose nach PT(C)A ist der limitierender Faktor dieser Therapie. Durch die loklae Pharmakotherapie versucht man die Restenose, deren histologisches Korrelat die Neointimahyperplasie durch Proliferation und Migration von glatten Muskelzellen darstellt, zu verhindern....
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2007
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| Online Access: | PDF Full Text |
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Efficient local drug therapy requires optimized application modalities to avoid vessel damage, wich might lead to increased neointimal hyperplasia. Aim of the study was to evaluate different application parameters for local delivery using the channeled balloon catheter in order to minimize vessel trauma induced by local application. Local application of drugs using the channeled balloon catheter is safe and feasible without significant neointimal hyperplasia compared to angioplasty if an application volume of 5 ml and a pressure of 4 atm is not exceeded.