Wachstumsverhalten neuroendokriner Tumorem als Prognosefaktor

Das therapeutische Management von Patienten mit GEP-Tumoren stellt aufgrund der Heterogenität eine Herausforderung dar und wird kontrovers diskutiert. Bei Erwägung einer antiproliferativen Therapie muss bedacht werden, dass der Spontanverlauf hinsichtlich des Tumorwachstums von Patient zu Patient a...

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Bibliographic Details
Main Author: Badihian, Tina
Contributors: Arnold, Rudolf (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2007
Online Access:PDF Full Text
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Neuroendocrine tumors constitute a rare and heterogeneous group of neoplasms. Little is known about spontaneous growth behaviour and prognostic parameters in well differentiated GEP-tumors. The purpose of this study was therefore to determine the growth behaviour of tumor lesions in patients with untreated GEP-tumors and to assess its influence on survival. Although there seems to be some correlation between growth behaviour and proliferation index both parameters may be of prognostic value in patients with well differentiated GEP-tumors. Patients who do not develop tumor progression within 12.5 months represent a prognostic favourable subgroup. In these patients an expectant strategy may be justfied.