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The histone acetyl transferase Tip60 as a regulator of tumor suppression

Tip60 is a histone acetyl transferase (HAT) and a cofactor of transcription, but also an interaction partner of the Mdm2 oncoprotein. The functional consequences of this interaction are only partially understood and were further explored in this study. We found that Tip60 expression leads to an incr...

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Bibliographic Details
Main Author: Dohmesen, Christoph
Contributors: Bölker, Michael (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2007
Subjects:
Biowissenschaften, Biologie
PML nuclear bodies
Apoptosis
Tumorsuppressor-Gen
Ubiquitin-like modifiers
Protein MDM2
Histone acetyl transferase
Histon-Acetyltransferase
Protea
His-tag-Pulldown
Ubiquitin-Protein-Ligase
UV-irradiation
Neddylierung
Ubiquitin-ähnliche Proteine
Ultraviolett-Bestrahlung
Protein TIP60, NEDD8
Neddylation
Protein p53
Life sciences
Online Access:PDF Full Text
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