Characterization of Binding Pocket Flexibility of Aldose Reductase

Characterization of Binding Pocket Flexibility of Aldose Reductase

Aldose Reductase (AR) is the first enzyme of the 'sorbitol pathway'. It is an NADPH dependent enzyme and catalyzes the reduction of various aldehydes to the corresponding alcohols. Its binding pocket shows intrinsic flexibility which is mainly mediated by a small loop region. A specificity...

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Bibliographic Details
Main Author: Zentgraf, Matthias
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2006
Subjects:
Aldose Reduktase
Computational chemistry
Docking
Molekulardesign
Molecular dynamics
Molekularbewegung
Chemie
Chemistry & allied sciences
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Call Number: urn:nbn:de:hebis:04-z2006-08429
Publication Date: 2006-12-21
Date of Acceptance: 2006-11-16
Downloads: 90 (2024), 106 (2023), 87 (2022), 85 (2021), 101 (2020), 84 (2019), 57 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2006/0842
https://doi.org/10.17192/z2006.0842

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