The surfactin biosynthetic complex of Bacillus subtilis: COM domain-mediated biocombinatorial synthesis, and single step purification of native multi-modular NRPSs and multi-enzyme complexes

Most biosynthetic templates for the assembly of peptide natural products are composed of two or more nonribosomal peptide synthetases (NRPSs). For example, the surfactin biosynthetic complex consists of three NRPSs (SrfA-A, SrfA-B, and SrfA-C), which are encoded by the polycistronic srfA operon with...

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Bibliographic Details

Main Author:	Chiocchini, Claudia
Contributors:	Buckel, Wolfgang (Prof.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2006
Subjects:	Multienzymkomplex Multienzyme complexes Protein-protein communication Biochemistry, molecular biology Biowissenschaften, Biologie COM Domäne NRPS COM domains Protein-Protein-Wechselwirkung Life sciences
Online Access:	PDF Full Text
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