Regulation von Osteoprotegerin (OPG) und Receptor activator of nuclear factor-κB ligand (RANKL) in humanen Schilddrüsenkarzinomzellen

Regulation von Osteoprotegerin (OPG) und Receptor activator of nuclear factor-κB ligand (RANKL) in humanen Schilddrüsenkarzinomzellen

Zusammenfassung RANKL (Receptor activator of nuclear factor κB ligand) und OPG (Osteoprotegerin), beides Mitglieder der TNF-Superfamilie, sind als Agonist und Antagonist eines neuen Zytokinsystems bisher in einer Vielzahl von Geweben und Zellsystemen beschrieben worden. Das RANKL/OPG-System spiel...

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Bibliographic Details
Main Author: Brulez, Nele
Contributors: Hofbauer, Lorenz (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2006
Subjects:
OPG
Schilddrüse
Schilddrüsenkarzinom
Medizin
Thyroid
RANKL
Thyroid cancer
Medical sciences Medicine
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The dissertation is concerned with the evidence and regulation of OPG (Osteoprotegerin) and RANKL (Receptor activator of nuclear factor ĸB ligand) in human thyroid cancer cells. The cells used were SW579 (anaplastic), HTC+ and XTC (both follicular). These were stimulated with steroid hormones, drugs and Il-1β and examined by Northern blot and ELISA.

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