Untersuchung neuroprotektiver Effekte der intrathekalen Baclofenapplikation

Cerebral-ischämische Erkrankungen nehmen eine wichtige Rolle bei der Versorgung neurologischer und neurochirurgischer Patienten ein. Sie sind darüberhinaus ein enormer gesundheitsökonomischer Faktor. Während die Erkenntnisse über die Pathophysiologie dieser Erkrankungen in den letzten Jahrzehnten...

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Bibliographic Details
Main Author: Ludolph, Alexander
Contributors: Becker, Ralf (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2006
Online Access:PDF Full Text
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Purpose of the present study is the examination of putative neuroprotective effects of intrathecally administered Baclofen in a modified four vessel occlusion model of transient global cerebral ischemia. Two treatment groups were formed. A dose of 1,5 µg baclofen has been given half an hour before and after ten minutes of global cerebral ischemia in either group. Histological examination of hippocampal CA1 area was performed one week after application and compared to control animals. Physiological parameters like body core and cranial temperature, respiratory parameters, blood glucose levels and mean arterial blood pressure were recorded for further analysis.