Structural and Functional Studies of tRNA-Guanine Transglycosylase: A putative Drug Target for Shigellosis Therapy

In this study structure-based drug design approaches for Zymomonas mobilis tRNA - guanine transglycosylase (TGT) are presented. In Shigella sp., the causative agent of bacterial shigellosis, TGT is involved in pathogenicity. Concerning the amino acid sequence, TGTs from both genera are highly h...

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Bibliographic Details

Main Author:	Stengl, Bernhard
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2006
Subjects:	TGT Basenaustausch Base exchange Aminoacyl-tRNS Transglycosylase Enzyminhibitor Structure-based drug design lin-Benzoguanin Medizin Transglykosylase Shigella Strukturbasiertes Design tRNA Kristallstrukturanalyse Zymomonas mobilis Bakterienruhr Medical sciences Medicine
Online Access:	PDF Full Text
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