Chemoenzymatic and Template-Directed Synthesis of Bioactive Macrocyclic Peptides

Nonribosomal peptide synthetases (NRPS) are large multienzyme complexes, which simultaneously represent template and biosynthetic machinery for the production of structurally diverse peptidic products that feature high pharmacological and biological activities. A key determinant of nonribosomal pept...

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Bibliographic Details

Main Author:	Grünewald, Jan
Contributors:	Marahiel, Mohamed (Prof.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2005
Subjects:	Lipopeptide Calcium-dependent antibiotic Peptidantibiotikum Peptide cyclases NRPS Chemie Zyklasen Daptomycin Peptidsynthetasen Lipopeptides Kalzium-abhängiges Antibiotikum Peptidderivate Cyclopeptide Chemistry & allied sciences
Online Access:	PDF Full Text
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