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Zetos: Ein Kulturbelastungssystem für trabekuläre Knochen. Eine Untersuchung zweier verschiedener Belastungssignale an bovinen Knochenzylindern
Ziel dieser Arbeit ist die Etablierung des ZETOS als Kultur- und Belastungssystem für trabekuläre Knochenzylinder. Dazu wurden während eines 26-tägigen Versuchs- bzw. 23-tägigen Belastungszeitraumes zwei Versuchsgruppen von jeweils acht Knochenzylindern, die aus dem Radius eines 18 Monate alten Kalb...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2005
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| Online Access: | PDF Full Text |
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The purpose of this work is the investigation of the ZETOS as a system for cultivation and mechanical stimulation of bone cores. During a 23 days period two different loading groups, each containing eight bone cores, were loaded with two different mechanical signals and compared to a non-loaded control-group. The first loading-signal corresponds to physiological walking ("walking"-signal), the second one to physiological jumping ("jumping"-signal). During the run both loading groups showes a clear increase of their apparent stiffness. The non-loaded control-group had neither a clear increase nor decrease. The increase of apparent stiffness was confirmed histologically by an appositional bone-growth in the form of osteoid.