Untersuchung der Plasmakonzentration von Diabetikern und Stoffwechselgesunden im Hinblick auf diabetogene Hormone unter besonderer Berücksichtigung von Resistin
Resistin ist ein kürzlich entdecktes Hormon, welches exklusiv im Fettgewebe synthetisiert wird. Die Synthese dieses Hormons ist supprimiert bei genetisch oder diätisch induzierter Adipositas im Tiermodell. Die Gabe von Resistin führt zu einer verschlechterten Glucosetoleranz und zu verminderter Insu...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2004
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| Online Access: | PDF Full Text |
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Resistin is a recently discovered hormone that is exclusively expressed in adipose tissue. Its expression in rodents was reported to be elevated or suppressed in genetic and diet-induced obesity, respectively. Resistin treatment impaired glucose tolerance and insulin action. Immunoneutralization of resistin improved insulin sensitivity, while thiazolidinedione treatment reduced resistin expression. Therefore, resistin could play a critical role in the development of obesity and type 2 diabetes. In this study were determined resistin plasma levels in humans suffering from type 1 and type 2 diabetes and in healthy controls. Plasma levels of resistin in healthy controls were 38.78 ng/ml. They were not statistically different in individuals with a broad BMI range. Resistin plasma levels in type 2 diabetes were 38.7 ng/ml, and 39.4 ng/ml in type 1 diabetes. Thiazolidinedione treatment did not influence resistin plasma levels. We conclude from our data: 1. resistin can be detected in human plasma, 2. plasma resistin levels are not different in type 1 and type 2 diabetes.