Volumetrische Analyse corticaler Areale bei Blinden und Sehenden im MRT
Angesichts der hohen Evidenz für die Plastizität des Gehirns stellt sich die Frage, ob das Gehirn bei sensorischer Deprivation, die mit dem deafferentierten Sinnessystem assoziierten Gehirnareale, nutzt und welche Auswirkungen die Deprivation auf die Morphologie des Kortex hat. E...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2004
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| Online Access: | PDF Full Text |
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Table of Contents:
Animal experiments have provided evidence for a
volumetric decrease in cortical grey matter following visual
deprivation. The present study investigated if structural
changes can be found in congenital blind humans. An MRI based
grey matter volumetric analysis was conducted with 10
congenital blind and 10 sighted adults. The groups were matched
in age and gender, and did not differ in body mass index (BMI),
Grey matter volume was determined for frontal, temporal,
occipital, parietal and cingulate lobes and in addition the
size of the lateral ventricles was measured. Only preterm born
blind adults showed a reduced total cortical grey matter volume
when compared with term born blind and term born sighted
humans. Since preterm born sighted subjects have reduced
cortical grey matter volume as well, these results suggest that
visual deprivation does not affect grey matter volume as
assessed by MRI analysis.