Volumetrische Analyse corticaler Areale bei Blinden und Sehenden im MRT

Angesichts der hohen Evidenz für die Plastizität des Gehirns stellt sich die Frage, ob das Gehirn bei sensorischer Deprivation, die mit dem deafferentierten Sinnessystem assoziierten Gehirnareale, nutzt und welche Auswirkungen die Deprivation auf die Morphologie des Kortex hat. E...

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Bibliographic Details
Main Author: Fleischer, Lars Ingo
Contributors: Bien, Siegfried Prof. Dr. med. (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2004
Online Access:PDF Full Text
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Table of Contents: Animal experiments have provided evidence for a volumetric decrease in cortical grey matter following visual deprivation. The present study investigated if structural changes can be found in congenital blind humans. An MRI based grey matter volumetric analysis was conducted with 10 congenital blind and 10 sighted adults. The groups were matched in age and gender, and did not differ in body mass index (BMI), Grey matter volume was determined for frontal, temporal, occipital, parietal and cingulate lobes and in addition the size of the lateral ventricles was measured. Only preterm born blind adults showed a reduced total cortical grey matter volume when compared with term born blind and term born sighted humans. Since preterm born sighted subjects have reduced cortical grey matter volume as well, these results suggest that visual deprivation does not affect grey matter volume as assessed by MRI analysis.