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Biodegradable Paclitaxel-loaded Nanoparticles and Stent Coatings as Local Delivery Systems for the Prevention of Restenosis
Despite improved technologies restenosis remains the main problem of catheter-based interventions after a percutaneous transluminal angioplasty in artery disease. Local and sustained application of antiproliferative agents is a promising approach to solve the problem of intimal hyper...
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| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2004
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| Online Access: | PDF Full Text |
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| Summary: | Despite improved technologies restenosis remains
the main problem of catheter-based interventions after a
percutaneous transluminal angioplasty in artery disease. Local
and sustained application of antiproliferative agents is a
promising approach to solve the problem of intimal hyperplasia.
In recent years, two different concepts for local drug delivery
have attained increased importance: On the one hand, colloidal
drug carriers, which can be infused directly into the vessel
wall during the angioplasty procedure using special delivery
catheters and on the other hand, the development of drug
eluting stents. Biocompatible, biodegradable polymers are one
of the most important instruments used to control the release
of pharmacological active substances. A new type of branched,
biodegradable polyesters, poly(vinyl
alcohol)-graft-poly(lactide-co-glycolide) (PVA-g-PLGA),
possesses very interesting features for the local and sustained
release of paclitaxel. Therefore, the objective of this work
was to investigate these polymers with regard to the
preparation of paclitaxel loaded nanoparticles and stent
coatings, and to evaluate their applicability as drug carriers
to prevent intimal hyperplasia. |
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| DOI: | 10.17192/z2004.0098 |