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A New Method for Ligand-supported Homology Modelling of Protein Binding Sites: Development and Application to the neurokinin-1 receptor

In this thesis, a novel strategy (MOBILE (Modelling Binding Sites Including Ligand Information Explicitly)) was developed that models protein binding-sites simultaneously considering information about the binding mode of bioactive ligands during the homology modelling process. A...

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Bibliographic Details
Main Author: Evers, Andreas
Contributors: Klebe, Gerhard (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2003
Subjects:
Modellierung
GPCRs
GPCRs , Homologiemodellierung
Computational chemistry , Arzneimitteldesign
Medizin
Wirkstoff-Rezeptor-Bindung
homology modelling
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2004-00191
Publication Date: 2004-01-27
Date of Acceptance: 2003-11-10
Downloads: 117 (2024), 76 (2023), 39 (2022), 46 (2021), 26 (2020), 20 (2019), 34 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2004/0019
https://doi.org/10.17192/z2004.0019

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