A New Method for Ligand-supported Homology Modelling of Protein Binding Sites: Development and Application to the neurokinin-1 receptor

In this thesis, a novel strategy (MOBILE (Modelling Binding Sites Including Ligand Information Explicitly)) was developed that models protein binding-sites simultaneously considering information about the binding mode of bioactive ligands during the homology modelling process. A...

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Bibliographic Details

Main Author:	Evers, Andreas
Contributors:	Klebe, Gerhard (Prof.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	German
Published:	Philipps-Universität Marburg 2003
Subjects:	Modellierung GPCRs GPCRs , Homologiemodellierung Computational chemistry , Arzneimitteldesign Medizin Wirkstoff-Rezeptor-Bindung homology modelling Medical sciences Medicine
Online Access:	PDF Full Text
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