Starre biomimetische Adrenalinrezeptor-Modelle

Im Rahmen dieser Arbeit wurden starre biomimetische Rezeptoren auf Bisphosphonat-Basis für Catecholamine, die eine wichtige Klasse von Hormonen und Neurotransmittern darstellen, entwickelt und synthetisiert. Diese makrozyklischen oder pinzettenförmigen Wirtverbindungen wurden durch 1H-NMR-Titratione...

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Bibliographic Details
Main Author: Molt, Oliver
Contributors: Schrader, Thomas (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2003
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In this thesis rigid biomimetic receptors based on bisphosphonates were designed and synthesized for the recognition of catecholamines, an important class of hormones and neurotransmitters. The binding properties of these macrocyclic or tweezwers-shaped host molecules in polar solution were examined by 1H NMR titrations. Furthermore, the amphiphilic receptors were embedded in lipid monolayers at the air/water interface and showed strong and selective binding of adrenaline derivatives in this simple membrane model.