Mikrobielle Kontaminationskinetik von Beatmungssysemen bei künstlich beatmeten Patienten

Kontaminationskinetik von Beatmungssystemen bei künstlich beatmeten Patienten Die Inzidenz, eine Pneumonie zu erleiden liegt bei beatmeten Patienten zwischen 10% und 25% und ist damit um ein Vielfaches höher als bei nicht beatmeten Patienten. Aus präventiv-medizinischer Sicht kommt damit der Pro...

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Bibliographic Details
Main Author: Neubert, Thomas Rochus
Contributors: Mutters, Reinier (Prof. Dr. rer.nat. (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2002
Online Access:PDF Full Text
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Table of Contents: Abstract The purpose of this prospective randomized study is the analysis of bacterial colonization in ventilator circuits related to their characteristics and changing interval to determine the role of ventilator circuits in prevention of ventilator associated pneumonia (VAP) and to confirm the results of other studies of a decreasing risk of VAP at increasing ventilator circuit interval on a view of microbiologist. In a 12-bed surgical intensive care unit (SICU) of a 1100-bed primary care university hospital 62 patients requiring mechanical ventilation for more than 48 hours were enrolled in the study. Quality and quantity of bacterial colonization was determined at three locations of the ventilator-circuit. The bacterial colonization was compared in standard nonheated circuits (Circuit A) versus heated wire circuits (Circuit B) at two different ventilator circuit changing intervals. The results were related to the microbiological findings in the patient (stomach, oro-pharyngeale cavity, trachea) and to the development of pneumonia. The trend was clear: the longer the circuit changeout time, the lower the colonization with endogenous and exogenous microorganisms. Mainly endogenous pathogens were identified in ventilator circuits, that were microorganisms having been found in patient at first (endogenous contamination). The patients themselves were the main sources of the bacterial microorganism colonizing the circuit. In Circuit A, a system with more need of intervention and formation of potentially contaminated condensate, a higher rate of bacterial contamination was identified than in circuit B. In comparison circuit A versus circuit B we found significant differences (p < 0,05) in exogenous microbial colonization. The endogenous contamination extremely depends on the ventilation mode. In controlled ventilation mode the rate of circuit-contamination is significant lower than in ventilation mode with high possibility of self-breathing. Decreased manipulation of ventilator circuit by extending changing interval or using circuits with less need of intervention led to a significant lower rate of bacterial colonization and, published by other authors, to lower risk of VAP. But a relationship between the quality and quantity of colonization and the development of pneumonia could not to be proved. The circuit change interval should be prolonged at least 7 day and ventilator circuits with minimal need of intervention should be used to decrease the risk of VAP.