Myeloid-derived suppressor cells in influenza virus-induced asthma exacerbation
Myeloid-derived suppressor cells (MDSCs) are a phenotypically heterogenous group of cells that potently suppress the immune response. A growing body of evidence supports the important role of MDSCs in a variety of lung diseases, such as asthma. However, the role of MDSCs in asthma exacerbation ha...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2024
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| Subjects: | |
| Online Access: | PDF Full Text |
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| Summary: | Myeloid-derived suppressor cells (MDSCs) are a phenotypically heterogenous
group of cells that potently suppress the immune response. A growing body of
evidence supports the important role of MDSCs in a variety of lung diseases, such
as asthma. However, the role of MDSCs in asthma exacerbation has so far not
been investigated. Here, we studied the role of MDSCs in a murine model of
influenza virus-induced asthma exacerbation. BALB/c mice were exposed to
house dust mite (HDM) three times a week for a total of five weeks to induce a
chronic asthmatic phenotype, which was exacerbated by additional exposure to
the A/Hamburg/5/2009 hemagglutinin 1 neuraminidase 1 (H1N1) influenza virus.
Induction of lung inflammatory features, production of T helper (Th) 1- and Th2-
associated inflammatory cytokines in the lavage fluid and an increased airway
hyper-responsiveness were observed, establishing the asthma exacerbation
model. The number and activity of pulmonary M-MDSCs increased in
exacerbated asthmatic mice compared to non-exacerbated asthmatic mice.
Furthermore, depletion of MDSCs aggravated airway hyper-responsiveness in
exacerbated asthmatic mice. These findings further denote the role of MDSCs in
asthma and provide some of the first evidence supporting a potential important
role of MDSCs in asthma exacerbation. |
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| Item Description: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3389/fimmu.2024.1342497 |