Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation

The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the biological significance of this difference is not clear. Here, we used molecular dynamics simulation to model the effects...

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Bibliographic Details

Main Authors:	Elli, Stefano, Raffaini, Giuseppina, Guerrini, Marco, Kosakovsky Pond, Sergei, Matrosovich, Mikhail
Format:	Article
Language:	English
Published:	Philipps-Universität Marburg 2023
Subjects:	H5N1 influenza substrate specificity neuraminidase MD simulation Medizin natural selection Medical sciences Medicine
Online Access:	PDF Full Text
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