Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation

The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the biological significance of this difference is not clear. Here, we used molecular dynamics simulation to model the effects...

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Main Authors: Elli, Stefano, Raffaini, Giuseppina, Guerrini, Marco, Kosakovsky Pond, Sergei, Matrosovich, Mikhail
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
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Call Number: urn:nbn:de:hebis:04-es2024-08091
Publication Date: 2024-01-24
Source: Erstveröffentlichung: Elli S, Raffaini G, Guerrini M, Kosakovsky Pond S and Matrosovich M (2023) Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation. Front. Microbiol. 14:1309156. https://doi.org/10.3389/fmicb.2023.1309156
Downloads: 59 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0809
https://doi.org/10.3389/fmicb.2023.1309156