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Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis

Three GPN-loop GTPases, GPN1–GPN3, are central to the maturation and trafficking of eukaryotic RNA polymerase II. This GTPase family is widely represented in archaea but typically occurs as single paralogs. Structural analysis of the GTP- and GDP-bound states of the Sulfolobus acidocaldarius GPN enz...

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Bibliographic Details
Main Authors: Korf, Lukas, Ye, Xing, Vogt, Marian S., Steinchen, Wieland, Watad, Mohamed, van der Does, Chris, Tourte, Maxime, Sivabalasarma, Shamphavi, Albers, Sonja-Verena, Essen, Lars-Oliver,
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
RNA polymerase II
sulfolobus
GPN-loop
Chemie
allostery
GTPase
Chemistry & allied sciences
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Call Number: urn:nbn:de:hebis:04-es2024-08044
Publication Date: 2024-01-24
Source: Erstveröffentlichung: Korf L, Ye X, Vogt MS, Steinchen W, Watad M, van der Does C, Tourte M, Sivabalasarma S, Albers S-V, Essen L-O. Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis. mBio. 2023 Nov 14;14(6):e0085923. https://doi.org/10.1128/mbio.00859-23
Downloads: 42 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0804
https://doi.org/10.1128/mbio.00859-23

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